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Target
Oxytocin receptor
Ligand
BDBM50001351
Substrate
n/a
Meas. Tech.
ChEBML_149059
IC50
>10000±n/a nM
Citation
 Evans, BE; Leighton, JL; Rittle, KE; Gilbert, KF; Lundell, GF; Gould, NP; Hobbs, DW; DiPardo, RM; Veber, DF; Pettibone, DJ Orally active, nonpeptide oxytocin antagonists. J Med Chem 35:3919-27 (1992) [PubMed]  Article 
Target
Name:
Oxytocin receptor
Synonyms:
OT-R | OXYR_RAT | Otr | Oxtr | Oxytocin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42889.28
Organism:
RAT
Description:
Oxytocin OXTR RAT::P70536
Residue:
388
Sequence:
MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA
  
Inhibitor
Name:
BDBM50001351
Synonyms:
1-[5,6-dimethoxyspiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyridine)]-1-ylsulfonylmethyl]-7,7-dimethyl-(1S,4R)-bicyclo[2.2.1]heptan-2-one | CHEMBL340531
Type:
Small organic molecule
Emp. Form.:
C24H31NO4S
Mol. Mass.:
429.572
SMILES:
COc1ccc2C=CC3(CCN(CC3)S(=O)(=O)C[C@]34CCC(CC3=O)C4(C)C)c2c1 |c:6|
Structure:
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