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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50241016
Substrate
n/a
Meas. Tech.
ChEMBL_1669514 (CHEMBL4019402)
IC50
0.500000±n/a nM
Citation
 Walter, NM; Wentsch, HK; Bührmann, M; Bauer, SM; Döring, E; Mayer-Wrangowski, S; Sievers-Engler, A; Willemsen-Seegers, N; Zaman, G; Buijsman, R; Lämmerhofer, M; Rauh, D; Laufer, SA Design, Synthesis, and Biological Evaluation of Novel Type I J Med Chem 60:8027-8054 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50241016
Synonyms:
CHEMBL4077602
Type:
Small organic molecule
Emp. Form.:
C30H24FN3O3
Mol. Mass.:
493.5283
SMILES:
CNC(=O)c1ccc2CCc3cc(Nc4ccc(F)c(NC(=O)c5ccccc5)c4)ccc3C(=O)c2c1
Structure:
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