Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50241041
Substrate
n/a
Meas. Tech.
ChEMBL_1669514 (CHEMBL4019402)
IC50
24±n/a nM
Citation
 Walter, NM; Wentsch, HK; Bührmann, M; Bauer, SM; Döring, E; Mayer-Wrangowski, S; Sievers-Engler, A; Willemsen-Seegers, N; Zaman, G; Buijsman, R; Lämmerhofer, M; Rauh, D; Laufer, SA Design, Synthesis, and Biological Evaluation of Novel Type I J Med Chem 60:8027-8054 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50241041
Synonyms:
CHEMBL4072511
Type:
Small organic molecule
Emp. Form.:
C27H24FN3O5
Mol. Mass.:
489.495
SMILES:
OCCNC(=O)c1ccc2COc3cc(Nc4ccc(F)c(NC(=O)C5CC5)c4)ccc3C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: