Target
Mitogen-activated protein kinase 14
Ligand
BDBM50241043
Substrate
n/a
Meas. Tech.
ChEMBL_1669514 (CHEMBL4019402)
IC50
1.3±n/a nM
Citation
 Walter, NMWentsch, HKBührmann, MBauer, SMDöring, EMayer-Wrangowski, SSievers-Engler, AWillemsen-Seegers, NZaman, GBuijsman, RLämmerhofer, MRauh, DLaufer, SA Design, Synthesis, and Biological Evaluation of Novel Type I J Med Chem 60:8027-8054 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50241043
Synonyms:
CHEMBL4103075
Type:
Small organic molecule
Emp. Form.:
C27H23F2N3O3
Mol. Mass.:
475.4866
SMILES:
CNC(=O)c1ccc2CCc3cc(Nc4cc(NC(=O)C5CC5)c(F)cc4F)ccc3C(=O)c2c1
Structure:
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