Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 4
Ligand
BDBM11162
Substrate
n/a
Meas. Tech.
ChEMBL_1671400 (CHEMBL4021429)
IC50
46±n/a nM
Citation
Sattigeri, JA; Sethi, S; Davis, JA; Ahmed, S; Rayasam, GV; Jadhav, BG; Chilla, SM; Datta, D; Gadhave, A; Tulasi, VK; Jain, T; Voleti, S; Benjamin, B; Udupa, S; Jain, G; Singh, Y; Srinivas, K; Bansal, VS; Ray, A; Bhatnagar, PK; Cliffe, IA Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome. Bioorg Med Chem Lett 27:2313-2318 (2017) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
Cd26 | DPP4_MOUSE | Dipeptidyl peptidase IV | Dpp4
Type:
PROTEIN
Mol. Mass.:
87433.73
Organism:
Mus musculus
Description:
ChEMBL_1335112
Residue:
760
Sequence:
MKTPWKVLLGLLGVAALVTIITVPIVLLSKDEAAADSRRTYSLADYLKSTFRVKSYSLWWVSDFEYLYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVSPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRQLITEEKIPNNTQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHRITSTGEENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTSDGSSFYKIISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEALTSDYLYYISNQYKEMPGGRNLYKIQLTDHTNVKCLSCDLNPERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHRSTDHKELRVLEDNSALDRMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADASFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYRNSTVMSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLH
Inhibitor
Name:
BDBM11162
Synonyms:
(1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorobenzyl)propylamine | (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[3,4-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride | CHEMBL393336 | MK-0431 | Sitagliptin | Sitagliptin (13) | Triazolopiperazine Analogue 1 | US10479798, Compound MK0431
Type:
Small organic molecule
Emp. Form.:
C16H15F6N5O
Mol. Mass.:
407.3136
SMILES:
N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F |r|