Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50003199
Substrate
n/a
Meas. Tech.
ChEBML_50207
IC50
1600±n/a nM
Citation
 Tilley, JW; Danho, W; Shiuey, SJ; Kulesha, I; Swistok, J; Makofske, R; Michalewsky, J; Triscari, J; Nelson, D; Weatherford, S Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29. J Med Chem 35:3774-83 (1992) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50003199
Synonyms:
CHEMBL126008 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2-[2-{4-[2-carboxyamino-3-(4-sulfo-phenyl)-propionylamino]-benzoylamino}-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-succinamic acid
Type:
Small organic molecule
Emp. Form.:
C46H50N8O13S2
Mol. Mass.:
987.065
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(cc2)S(O)(=O)=O)NC(O)=O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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