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Target
Lysine-specific demethylase 4D
Ligand
BDBM50242881
Substrate
n/a
Meas. Tech.
ChEBML_1672325
IC50
1850±n/a nM
Citation
 Fang, Z; Wang, TQ; Li, H; Zhang, G; Wu, XA; Yang, L; Peng, YL; Zou, J; Li, LL; Xiang, R; Yang, SY Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors. Bioorg Med Chem Lett 27:3201-3204 (2017) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4D
Synonyms:
JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D
Type:
PROTEIN
Mol. Mass.:
58627.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102441
Residue:
523
Sequence:
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
  
Inhibitor
Name:
BDBM50242881
Synonyms:
CHEMBL4086607
Type:
Small organic molecule
Emp. Form.:
C12H9N5O
Mol. Mass.:
239.2328
SMILES:
CCc1nn2c(nc(O)c3cccnc23)c1C#N
Structure:
Search PDB for entries with ligand similarity: