Target
Acidic mammalian chitinase
Ligand
BDBM50243746
Substrate
n/a
Meas. Tech.
ChEMBL_1672910 (CHEMBL4022939)
IC50
8.7±n/a nM
Citation
 Mazur, MOlczak, JOlejniczak, SKoralewski, RCzestkowski, WJedrzejczak, AGolab, JDzwonek, KDymek, BSklepkiewicz, PLZagozdzon, ANoonan, TMahboubi, KConway, BSheeler, RBeckett, PHungerford, WMPodjarny, AMitschler, ACousido-Siah, AFadel, FGolebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem 61:695-710 (2018) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50243746
Synonyms:
CHEMBL4068944
Type:
Small organic molecule
Emp. Form.:
C19H29BrN6
Mol. Mass.:
421.378
SMILES:
CC(C)CN(CCc1ccc(Br)cc1)C1CCN(CC1)c1nc(N)n[nH]1
Structure:
Search PDB for entries with ligand similarity: