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TargetAcidic mammalian chitinase (AMCase)
LigandBDBM50243685
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1672910
IC50 3.4±n/a nM
Citation Mazur, MOlczak, JOlejniczak, SKoralewski, RCzestkowski, WJedrzejczak, AGolab, JDzwonek, KDymek, BSklepkiewicz, PLZagozdzon, ANoonan, TMahboubi, KConway, BSheeler, RBeckett, PHungerford, WMPodjarny, AMitschler, ACousido-Siah, AFadel, FGolebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem61:695-710 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acidic mammalian chitinase (AMCase)
Name:Acidic mammalian chitinase (AMCase)
Synonyms:AMCase | Lung-specific protein TSA1902
Type:Protein
Mol. Mass.:52266.66
Organism:Homo sapiens (Human)
Description:Q9BZP6
Residue:476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50243685
NameBDBM50243685
Synonyms:CHEMBL4084573
TypeSmall organic molecule
Emp. Form.C26H29ClN6
Mol. Mass.461.002
SMILESNc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1cccc2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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