Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50003668
Substrate
n/a
Meas. Tech.
ChEBML_50186
IC50
59±n/a nM
Citation
 Tilley, JW; Danho, W; Madison, V; Fry, D; Swistok, J; Makofske, R; Michalewsky, J; Schwartz, A; Weatherford, S; Triscari, J Analogs of CCK incorporating conformationally constrained replacements for Asp32. J Med Chem 35:4249-52 (1992) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50003668
Synonyms:
CHEMBL3143146 | [1-[1-[4-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-5,5-dimethyl-thiazolidine-3-carbonyl]-5-(3-o-tolyl-ureido)-pentylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C45H58N8O7S
Mol. Mass.:
855.056
SMILES:
Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(Cc1ccccc1)C(N)=O
Structure:
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