Reaction Details Report a problem with these data
Target
Phospholipase A2, major isoenzyme
Ligand
BDBM50004499
Substrate
n/a
Meas. Tech.
ChEMBL_156346 (CHEMBL759989)
IC50
230±n/a nM
Citation
Bennion, C; Connolly, S; Gensmantel, NP; Hallam, C; Jackson, CG; Primrose, WU; Roberts, GC; Robinson, DH; Slaich, PK Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex. J Med Chem 35:2939-51 (1992) [PubMed] Article
More Info.:
Target
Name:
Phospholipase A2, major isoenzyme
Synonyms:
Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2
Type:
Hydrolase; monomer or homodimer
Mol. Mass.:
16279.83
Organism:
Sus scrofa (pig)
Description:
Purchased from Sigma.
Residue:
146
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
Inhibitor
Name:
BDBM50004499
Synonyms:
(R)-O-(2-Hexadecanamidoisohexyl) phosphocholine | CHEMBL322409 | {2-[(2-Hexadecanoyl amino-4-methyl-p entyloxy)-hydroxy-phoryloxy]-ethyl}-trimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C27H57N2O5P
Mol. Mass.:
520.7256
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)CC(C)C