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Target
Carbonic anhydrase 2
Ligand
BDBM50004554
Substrate
n/a
Meas. Tech.
ChEMBL_45061 (CHEMBL658057)
Ki
3.6±n/a nM
Citation
 Hartman, GD; Halczenko, W; Prugh, JD; Smith, RL; Sugrue, MF; Mallorga, P; Michelson, SR; Randall, WC; Schwam, H; Sondey, JM Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors. J Med Chem 35:3027-33 (1992) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50004554
Synonyms:
5-{[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethyl)-amino]-methyl}-thieno[2,3-b]furan-2-sulfonic acid amide | CHEMBL103255
Type:
Small organic molecule
Emp. Form.:
C15H24N2O6S2
Mol. Mass.:
392.491
SMILES:
COCCOCCN(CCOC)Cc1cc2cc(oc2s1)S(N)(=O)=O
Structure:
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