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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM50249228
Substrate
n/a
Meas. Tech.
ChEMBL_1679755 (CHEMBL4030032)
IC50
17±n/a nM
Citation
 Dong, S; VanGelder, K; Shi, ZC; Yu, Y; Wu, Z; Ferguson, R; Guo, ZZ; Tang, H; Frie, J; Fu, Q; Gu, X; Priest, BT; Thomas-Fowlkes, B; Weinglass, A; Margulis, M; Liu, J; Pai, LY; Hampton, C; Haimbach, RE; Owens, K; Tong, V; Xu, S; Hu, M; Zingaro, GJ; Morissette, P; Ehrhart, J; Roy, S; Sullivan, K; Pasternak, A Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett 27:2559-2566 (2017) [PubMed]  Article 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM50249228
Synonyms:
CHEMBL4075319
Type:
Small organic molecule
Emp. Form.:
C22H26N4O5S
Mol. Mass.:
458.531
SMILES:
COc1nsc(n1)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r|
Structure:
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