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TargetCyclic GMP-AMP synthase
LigandBDBM50250107
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1680904
IC50 125000±n/a nM
Citation Hall, JBrault, AVincent, FWeng, SWang, HDumlao, DAulabaugh, AAivazian, DCastro, DChen, MCulp, JDower, KGardner, JHawrylik, SGolenbock, DHepworth, DHorn, MJones, LJones, PLatz, ELi, JLin, LLLin, WLin, DLovering, FNiljanskul, NNistler, RPierce, BPlotnikova, OSchmitt, DShanker, SSmith, JSnyder, WSubashi, TTrujillo, JTyminski, EWang, GWong, JLefker, BDakin, LLeach, K Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE12:1-16 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclic GMP-AMP synthase
Name:Cyclic GMP-AMP synthase
Synonyms:2''3''-cGAMP synthase | 2.7.7.86 | CGAS | Cyclic GMP-AMP synthase | MB21D1 | Mab-21 domain-containing protein 1 | Synonyms=C6orf150 | cGAMP synthase | cGAS | h-cGAS
Type:PROTEIN
Mol. Mass.:58845.55
Organism:Homo sapiens
Description:ChEMBL_117333
Residue:522
Sequence:
MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
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BDBM50250107
NameBDBM50250107
Synonyms:CHEMBL4085628
TypeSmall organic molecule
Emp. Form.C14H12N4O2
Mol. Mass.268.2707
SMILESCNC(=O)c1cnn2c(O)cc(nc12)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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