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Target
Stromelysin-2
Ligand
BDBM50250161
Substrate
n/a
Meas. Tech.
ChEMBL_1681097 (CHEMBL4031374)
IC50
30±n/a nM
Citation
 Senn, N; Ott, M; Lanz, J; Riedl, R Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor. J Med Chem 60:9585-9598 (2017) [PubMed]  Article 
Target
Name:
Stromelysin-2
Synonyms:
MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2
Type:
Enzyme
Mol. Mass.:
54143.02
Organism:
Homo sapiens (Human)
Description:
P09238
Residue:
476
Sequence:
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
  
Inhibitor
Name:
BDBM50250161
Synonyms:
CHEMBL4071820
Type:
Small organic molecule
Emp. Form.:
C25H19FN4O5
Mol. Mass.:
474.4406
SMILES:
COc1cc(CNC(=O)C#Cc2cn(Cc3ccc(cc3)-c3cnco3)c(=O)[nH]c2=O)ccc1F
Structure:
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