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Target
Dual specificity protein phosphatase 10
Ligand
BDBM50250606
Substrate
n/a
Meas. Tech.
ChEBML_1681980
Ki
6900±n/a nM
Citation
 Witten, MR; Wissler, L; Snow, M; Geschwindner, S; Read, JA; Brandon, NJ; Nairn, AC; Lombroso, PJ; Käck, H; Ellman, JA X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J Med Chem 60:9299-9319 (2017) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 10
Synonyms:
DUS10_HUMAN | DUSP10 | Dual specificity protein phosphatase 10 | MAP kinase phosphatase 5 | MKP-5 | MKP5 | Mitogen-activated protein kinase phosphatase 5 | Mitogen-activated protein kinase phosphatase 5 (MKP5)
Type:
Enzyme
Mol. Mass.:
52649.12
Organism:
Homo sapiens (Human)
Description:
Q9Y6W6
Residue:
482
Sequence:
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV
  
Inhibitor
Name:
BDBM50250606
Synonyms:
CHEMBL4077342
Type:
Small organic molecule
Emp. Form.:
C24H21Cl3F2NO6PS
Mol. Mass.:
626.821
SMILES:
OP(O)(=O)C(F)(c1ccc(cc1)-c1cccc(Cc2cc(Cl)c(Cl)cc2Cl)c1F)S(=O)(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: