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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50006469
Substrate
n/a
Meas. Tech.
ChEBML_31769
IC50
2.1±n/a nM
Citation
 Mylari, BL; Zembrowski, WJ; Beyer, TA; Aldinger, CE; Siegel, TW Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives. J Med Chem 35:2155-62 (1992) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50006469
Synonyms:
CHEMBL69956 | [8-Oxo-7-(5-trifluoromethyl-benzothiazol-2-ylmethyl)-7,8-dihydro-pyrido[2,3-d]pyridazin-5-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C18H11F3N4O3S
Mol. Mass.:
420.365
SMILES:
OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ncccc12
Structure:
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