Reaction Details Report a problem with these data
Target
Interleukin-6
Ligand
BDBM50252381
Substrate
n/a
Meas. Tech.
ChEBML_1684684
IC50
5800±n/a nM
Citation
 Kim, D; Won, HY; Hwang, ES; Kim, YK; Choo, HP Synthesis of benzoxazole derivatives as interleukin-6 antagonists. Bioorg Med Chem 25:3127-3134 (2017) [PubMed]  Article 
Target
Name:
Interleukin-6
Synonyms:
B-cell stimulatory factor 2 | BSF-2 | CDF | CTL differentiation factor | Hybridoma growth factor | IFN-beta-2 | IFNB2 | IL-6 | IL6 | IL6_HUMAN | Interferon beta-2
Type:
n/a
Mol. Mass.:
23717.96
Organism:
Homo sapiens (Human)
Description:
P05231
Residue:
212
Sequence:
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
  
Inhibitor
Name:
BDBM50252381
Synonyms:
CHEMBL4080826
Type:
Small organic molecule
Emp. Form.:
C22H19N3O2
Mol. Mass.:
357.4052
SMILES:
CCc1ccc(Nc2nc3cc(NC(=O)c4ccccc4)ccc3o2)cc1
Structure:
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