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Target
Cytosolic endo-beta-N-acetylglucosaminidase
Ligand
BDBM50070208
Substrate
n/a
Meas. Tech.
ChEBML_1685304
IC50
24380±n/a nM
Citation
 Bi, Y; Might, M; Vankayalapati, H; Kuberan, B Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-?-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett 27:2962-2966 (2017) [PubMed]  Article 
Target
Name:
Cytosolic endo-beta-N-acetylglucosaminidase
Synonyms:
ENASE_HUMAN | ENGASE | Endo-beta-N-acetylglucosaminidase
Type:
PROTEIN
Mol. Mass.:
83989.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_467019
Residue:
743
Sequence:
MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFREVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSSQRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTAHRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSLSLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGFFTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEAVGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAVRLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLRPLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCRLGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRCFRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPVPKEGFRVPQAEWGRAVLLYSAPA
  
Inhibitor
Name:
BDBM50070208
Synonyms:
A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Prevacid | Prevacid 24hr | Prevacid Delayed Release | Prevacid Solutab | Prevacid iv
Type:
Small organic molecule
Emp. Form.:
C16H14F3N3O2S
Mol. Mass.:
369.361
SMILES:
Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1
Structure:
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