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Target
D(2) dopamine receptor
Ligand
BDBM50007139
Substrate
n/a
Meas. Tech.
ChEMBL_62257 (CHEMBL675484)
Ki
764±n/a nM
Citation
 DeNinno, MP; Schoenleber, R; Perner, RJ; Lijewski, L; Asin, KE; Britton, DR; MacKenzie, R; Kebabian, JW Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. J Med Chem 34:2561-9 (1991) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50007139
Synonyms:
1-Aminomethyl-3-(3-methoxy-phenyl)-isochroman-5,6-diol | CHEMBL315005
Type:
Small organic molecule
Emp. Form.:
C17H19NO4
Mol. Mass.:
301.3371
SMILES:
COc1cccc(c1)C1Cc2c(O)c(O)ccc2[C@H](CN)O1
Structure:
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