Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50007162
Substrate
n/a
Meas. Tech.
ChEBML_145222
Ki
>100±n/a nM
Citation
 Vecchietti, V; Clarke, GD; Colle, R; Giardina, G; Petrone, G; Sbacchi, M (1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics. J Med Chem 34:2624-33 (1991) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50007162
Synonyms:
2-(3,4-Dichloro-phenyl)-1-(1-pyrrolidin-1-ylmethyl-1,3,4,9-tetrahydro-beta-carbolin-2-yl)-ethanone;HCl | CHEMBL329343
Type:
Small organic molecule
Emp. Form.:
C24H25Cl2N3O
Mol. Mass.:
442.381
SMILES:
Clc1ccc(CC(=O)N2CCc3c([nH]c4ccccc34)C2CN2CCCC2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: