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Target
D(2) dopamine receptor
Ligand
BDBM50007557
Substrate
n/a
Meas. Tech.
ChEMBL_58695 (CHEMBL672661)
IC50
86±n/a nM
Citation
 Lowe, JA; Seeger, TF; Nagel, AA; Howard, HR; Seymour, PA; Heym, JH; Ewing, FE; Newman, ME; Schmidt, AW; Furman, JS 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem 34:1860-6 (1991) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50007557
Synonyms:
3,3-Dimethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-yl)-ethyl]-1,3-dihydro-indol-2-one | CHEMBL294702
Type:
Small organic molecule
Emp. Form.:
C26H29N3O
Mol. Mass.:
399.528
SMILES:
CC1(C)C(=O)Nc2ccc(CCN3CCN(CC3)c3cccc4ccccc34)cc12
Structure:
Search PDB for entries with ligand similarity: