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Target
Proteasome subunit beta type-1
Ligand
BDBM50259657
Substrate
n/a
Meas. Tech.
ChEBML_1691540
IC50
30±n/a nM
Citation
 Han, LQ; Yuan, X; Wu, XY; Li, RD; Xu, B; Cheng, Q; Liu, ZM; Zhou, TY; An, HY; Wang, X; Cheng, TM; Ge, ZM; Cui, JR; Li, RT Urea-containing peptide boronic acids as potent proteasome inhibitors. Eur J Med Chem 125:925-939 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50259657
Synonyms:
CHEMBL4068221
Type:
Small organic molecule
Emp. Form.:
C23H32BN3O4
Mol. Mass.:
425.329
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N(C)Cc1ccccc1)B(O)O |r|
Structure:
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