Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50009796
Substrate
n/a
Meas. Tech.
ChEBML_157078
IC50
15±n/a nM
Citation
 Mylari, BLLarson, ERBeyer, TAZembrowski, WJAldinger, CEDee, MFSiegel, TWSingleton, DH Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. J Med Chem 34:108-22 (1991) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50009796
Synonyms:
(3-Benzothiazol-2-ylmethyl-6-chloro-4-oxo-3,4-dihydro-phthalazin-1-yl)-acetic acid | CHEMBL20796
Type:
Small organic molecule
Emp. Form.:
C18H12ClN3O3S
Mol. Mass.:
385.824
SMILES:
OC(=O)Cc1nn(Cc2nc3ccccc3s2)c(=O)c2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: