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Target
Cathepsin D
Ligand
BDBM50009901
Substrate
n/a
Meas. Tech.
ChEBML_45146
IC50
5403±n/a nM
Citation
 Doherty, AM; Kaltenbronn, JS; Hudspeth, JP; Repine, JT; Roark, WH; Sircar, I; Tinney, FJ; Connolly, CJ; Hodges, JC; Taylor, MD New inhibitors of human renin that contain novel replacements at the P2 site. J Med Chem 34:1258-71 (1991) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_BOVIN | CTSD
Type:
PROTEIN
Mol. Mass.:
42158.92
Organism:
Bos taurus
Description:
ChEMBL_1458606
Residue:
387
Sequence:
VIRIPLHKFTSIRRTMSEAAGVLIAKGPISKYATGEPAVRQGPIPELLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSANLWVPSIHCKLLDIACWTHRKYNSDKSSTYVKNGTTFDIHYGSGSLSGYLSQDTVSVPCNPSSSSPGGVTVQRQTFGEAIKQPGVVFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDKNVFSFFLNRDPKAQPGGELMLGGTDSKYYRGSLMFHNVTRQAYWQIHMDQLDVGSSLTVCKGGCEAIVDTGTSLIVGPVEEVRELQKAIGAVPLIQGEYMIPCEKVSSLPEVTVKLGGKDYALSPEDYALKVSQAETTVCLSGFMGMDIPPPGGPLWILGDVFIGRYYTVFDRDQNRVGLAEAARL
  
Inhibitor
Name:
BDBM50009901
Synonyms:
6-(3-Methyl-thioureido)-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-hexanoic acid {4-[2-(2-amino-ethyl)-morpholin-4-yl]-2-hydroxy-1-isobutyl-4-oxo-butyl}-amide | CHEMBL281134
Type:
Small organic molecule
Emp. Form.:
C46H62N6O5S
Mol. Mass.:
811.087
SMILES:
CNC(=S)NCCCCC(NC(=O)C(Cc1cccc2ccccc12)Cc1cccc2ccccc12)C(=O)NC(CC(C)C)[C@@H](O)CC(=O)N1CCOC(CCN)C1
Structure:
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