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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50010151
Substrate
n/a
Meas. Tech.
ChEBML_36482
IC50
4600±n/a nM
Citation
 Bühlmayer, P; Criscione, L; Fuhrer, W; Furet, P; de Gasparo, M; Stutz, S; Whitebread, S Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives. J Med Chem 34:3105-14 (1991) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50010151
Synonyms:
6-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-ylmethyl)-2-methyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid | CHEMBL107271
Type:
Small organic molecule
Emp. Form.:
C21H27ClN2O3
Mol. Mass.:
390.904
SMILES:
CCCCc1nc(Cl)c(CO)n1Cc1ccc2CC(C)(CCc2c1)C(O)=O
Structure:
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