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Target
Solute carrier family 22 member 3
Ligand
BDBM50420178
Substrate
n/a
Meas. Tech.
ChEMBL_1695439 (CHEMBL4046329)
IC50
2200000±n/a nM
Citation
 Pan, X; Iyer, KA; Liu, H; Sweet, DH; Dukat, M A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3). Bioorg Med Chem Lett 27:4440-4445 (2017) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 3
Synonyms:
EMT | EMTH | Extraneuronal monoamine transporter | OCT3 | Organic cation transporter 3 | S22A3_HUMAN | SLC22A3
Type:
PROTEIN
Mol. Mass.:
61292.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_934315
Residue:
556
Sequence:
MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
  
Inhibitor
Name:
BDBM50420178
Synonyms:
GUANIDINE
Type:
Small organic molecule
Emp. Form.:
CH5N3
Mol. Mass.:
59.0705
SMILES:
NC(N)=N
Structure:
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