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TargetAldose reductase (AR)
LigandBDBM50010443
Substrate/Competitorn/a
Meas. Tech.ChEBML_218061
Ki 9700.0±n/a nM
Citation Deck, LMVander Jagt, DLRoyer, RE Gossypol and derivatives: a new class of aldose reductase inhibitors. J Med Chem34:3301-5 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (AR)
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50010443
NameBDBM50010443
Synonyms:1,1'-Dihydroxy-5,5'-diisopropyl-6,7,6',7'-tetramethoxy-3,3'-dimethyl-[2,2']binaphthalenyl-8,8'-dicarbaldehyde | CHEMBL325738
TypeSmall organic molecule
Emp. Form.C34H38O8
Mol. Mass.574.6607
SMILESCOc1c(OC)c(C(C)C)c2cc(C)c(c(O)c2c1C=O)-c1c(C)cc2c(C(C)C)c(OC)c(OC)c(C=O)c2c1O |(1.57,-11.37,;2.92,-10.58,;4.26,-11.35,;4.26,-12.91,;2.92,-13.69,;1.57,-12.91,;5.59,-13.65,;5.59,-15.21,;6.92,-15.98,;4.26,-15.98,;6.92,-12.91,;8.21,-13.65,;9.55,-12.91,;9.55,-14.01,;9.55,-11.35,;8.21,-10.58,;8.21,-9.03,;6.92,-11.35,;5.59,-10.58,;5.59,-9.03,;4.26,-8.26,;12.21,-11.35,;12.21,-12.91,;12.24,-14.01,;13.55,-13.65,;14.86,-12.91,;16.19,-13.65,;16.19,-15.21,;17.54,-15.98,;14.86,-15.98,;17.54,-12.91,;18.85,-13.69,;20.21,-12.91,;17.54,-11.35,;18.85,-10.58,;20.21,-11.35,;16.19,-10.58,;16.18,-9.03,;17.51,-8.26,;14.86,-11.35,;13.55,-10.58,;13.55,-9.03,)|
Structure
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