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TargetAldose reductase (AR)
LigandBDBM50010442
Substrate/Competitorn/a
Meas. Tech.ChEBML_218061
Ki 56000±n/a nM
Citation Deck, LMVander Jagt, DLRoyer, RE Gossypol and derivatives: a new class of aldose reductase inhibitors. J Med Chem34:3301-5 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (AR)
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50010442
NameBDBM50010442
Synonyms:5,5'-Diisopropyl-1,6,7,1',6',7'-hexamethoxy-3,3'-dimethyl-[2,2']binaphthalenyl-8,8'-dicarbaldehyde | CHEMBL109986
TypeSmall organic molecule
Emp. Form.C36H42O8
Mol. Mass.602.7139
SMILESCOc1c(OC)c(C(C)C)c2cc(C)c(c(OC)c2c1C=O)-c1c(C)cc2c(C(C)C)c(OC)c(OC)c(C=O)c2c1OC |(1.43,-5.97,;2.77,-5.2,;4.1,-5.97,;4.1,-7.53,;2.77,-8.31,;1.41,-7.55,;5.43,-8.28,;5.43,-9.83,;4.1,-10.62,;6.77,-10.62,;6.77,-7.53,;8.07,-8.28,;9.38,-7.53,;9.38,-8.65,;9.38,-5.97,;8.07,-5.2,;8.07,-3.66,;9.41,-2.88,;6.77,-5.97,;5.43,-5.2,;5.43,-3.66,;6.77,-2.9,;12.07,-5.97,;12.07,-7.53,;12.09,-8.65,;13.38,-8.28,;14.71,-7.53,;16.02,-8.28,;16.02,-9.83,;17.38,-10.62,;14.71,-10.62,;17.38,-7.53,;18.71,-8.31,;20.05,-7.56,;17.38,-5.97,;18.71,-5.2,;20.05,-5.97,;16.02,-5.2,;16.02,-3.66,;17.38,-2.9,;14.71,-5.97,;13.38,-5.2,;13.38,-3.66,;12.05,-2.9,)|
Structure
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