Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50263207
Substrate
n/a
Meas. Tech.
ChEBML_1697703
EC50
18±n/a nM
Citation
 Aurelio, L; Baltos, JA; Ford, L; Nguyen, ATN; Jörg, M; Devine, SM; Valant, C; White, PJ; Christopoulos, A; May, LT; Scammells, PJ A Structure-Activity Relationship Study of Bitopic N J Med Chem 61:2087-2103 (2018) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50263207
Synonyms:
CHEMBL4086624
Type:
Small organic molecule
Emp. Form.:
C27H32N6O5S
Mol. Mass.:
552.645
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCCCCCCNC(=O)c3cccc(c3)-c3cccs3)ncnc12 |r|
Structure:
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