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Target
Procathepsin L
Ligand
BDBM50263573
Substrate
n/a
Meas. Tech.
ChEBML_1698166
Ki
24±n/a nM
Citation
 Giroud, M; Dietzel, U; Anselm, L; Banner, D; Kuglstatter, A; Benz, J; Blanc, JB; Gaufreteau, D; Liu, H; Lin, X; Stich, A; Kuhn, B; Schuler, F; Kaiser, M; Brun, R; Schirmeister, T; Kisker, C; Diederich, F; Haap, W Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors. J Med Chem 61:3350-3369 (2018) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50263573
Synonyms:
CHEMBL4080708
Type:
Small organic molecule
Emp. Form.:
C24H18ClF2N3O4
Mol. Mass.:
485.867
SMILES:
Fc1cc(F)c2OCC#CCOc3ccc(C[C@H](NC(=O)c2c1)C(=O)NC1(CC1)C#N)cc3Cl |r|
Structure:
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