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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50011418
Substrate
n/a
Meas. Tech.
ChEBML_210731
IC50
1200±n/a nM
Citation
 Cushman, M; Nagarathnam, D; Burg, DL; Geahlen, RL Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. J Med Chem 34:798-806 (1991) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50011418
Synonyms:
2-(4-Amino-phenyl)-6-hydroxy-chromen-4-one | 2-(4-aminophenyl)-6-hydroxy-4H-chromen-4-one | 4'-amino-6-hydroxyflavone | CHEMBL166851
Type:
Small organic molecule
Emp. Form.:
C15H11NO3
Mol. Mass.:
253.2527
SMILES:
Nc1ccc(cc1)-c1cc(=O)c2cc(O)ccc2o1
Structure:
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