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Target
Platelet-activating factor receptor
Ligand
BDBM50011635
Substrate
n/a
Meas. Tech.
ChEBML_56498
IC50
0.200000±n/a nM
Citation
 Walser, A; Flynn, T; Mason, C; Crowley, H; Maresca, C; Yaremko, B; O'Donnell, M Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor. J Med Chem 34:1209-21 (1991) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50011635
Synonyms:
1-{3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-3,4-dihydro-1H-quinolin-2-one | CHEMBL277701
Type:
Small organic molecule
Emp. Form.:
C27H20ClN5OS
Mol. Mass.:
497.999
SMILES:
Cc1nnc2CN=C(c3cc(sc3-n12)C#CCN1C(=O)CCc2ccccc12)c1ccccc1Cl |c:6|
Structure:
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