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Target
Gastrin-releasing peptide receptor
Ligand
BDBM50012304
Substrate
n/a
Meas. Tech.
ChEMBL_206637 (CHEMBL810154)
IC50
1.8±n/a nM
Citation
 Heimbrook, DC; Saari, WS; Balishin, NL; Fisher, TW; Friedman, A; Kiefer, DM; Rotberg, NS; Wallen, JW; Oliff, A Gastrin releasing peptide antagonists with improved potency and stability. J Med Chem 34:2102-7 (1991) [PubMed]  Article 
Target
Name:
Gastrin-releasing peptide receptor
Synonyms:
GRP-R | GRP-preferring bombesin receptor | GRPR_MOUSE | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor | Grpr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43234.59
Organism:
MOUSE
Description:
Gastrin-Releasing peptide 0 MOUSE::P21729
Residue:
384
Sequence:
MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
  
Inhibitor
Name:
BDBM50012304
Synonyms:
2-{2-[2-[2-(2,2-Dimethyl-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-N-{[2-(3H-imidazol-4-yl)-1-(1-isobutyl-hexylcarbamoyl)-ethylcarbamoyl]-methyl}-3-methyl-butyramide | CHEMBL302612
Type:
Small organic molecule
Emp. Form.:
C48H72N12O7
Mol. Mass.:
929.1615
SMILES:
CCCCC[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C(C)(C)C)C(C)C
Structure:
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