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Target
Kappa-type opioid receptor
Ligand
BDBM50269278
Substrate
n/a
Meas. Tech.
ChEMBL_1705795 (CHEMBL4057028)
EC50
0.025000±n/a nM
Citation
 Suzuki, S; Sugawara, Y; Tsuji, R; Tanimura, R; Kaneko, C; Yuzawa, N; Yagi, M; Kawai, K Discovery of highly selective?-opioid receptor agonists: 10?-Hydroxy TRK-820 derivatives. Bioorg Med Chem Lett 27:3920-3924 (2017) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50269278
Synonyms:
CHEMBL4103819
Type:
Small organic molecule
Emp. Form.:
C28H32N2O6
Mol. Mass.:
492.5635
SMILES:
[H][C@@]12Oc3c4c(ccc3O)[C@H](O)[C@@]3([H])N(CC5CC5)CC[C@@]14[C@@]3(O)CC[C@H]2N(C)C(=O)\C=C\c1ccoc1 |r,THB:15:14:22:4.5.10|
Structure:
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