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Target
Beta-1 adrenergic receptor
Ligand
BDBM50272481
Substrate
n/a
Meas. Tech.
ChEMBL_1712282 (CHEMBL4122331)
IC50
106±n/a nM
Citation
 Kubacka, M; Szkaradek, N; Mogilski, S; Pa?czyk, K; Siwek, A; Grybo?, A; Filipek, B; ?mudzki, P; Marona, H; Waszkielewicz, AM Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone. Bioorg Med Chem 26:3773-3784 (2018) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2
Type:
Protein
Mol. Mass.:
50486.84
Organism:
Rattus norvegicus (Rat)
Description:
P18090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM50272481
Synonyms:
CHEMBL4128940
Type:
Small organic molecule
Emp. Form.:
C26H28ClNO6
Mol. Mass.:
485.957
SMILES:
Cl.COc1ccc(CCNCC(O)COc2cccc3c2oc2ccccc2c3=O)cc1OC
Structure:
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