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Target
Lysine-specific demethylase 7A
Ligand
BDBM50273477
Substrate
n/a
Meas. Tech.
ChEMBL_1712926 (CHEMBL4122975)
IC50
68000±n/a nM
Citation
 Bhushan, B; Erdmann, A; Zhang, Y; Belle, R; Johannson, C; Oppermann, U; Hopkinson, RJ; Schofield, CJ; Kawamura, A Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorg Med Chem 26:2984-2991 (2018) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 7A
Synonyms:
JHDM1D | JmjC domain-containing histone demethylation protein 1D | KDM7 | KDM7A | KDM7A_HUMAN | KIAA1718 | Lysine-specific demethylase 7 | Lysine-specific demethylase 7A/7B
Type:
PROTEIN
Mol. Mass.:
106577.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_859443
Residue:
941
Sequence:
MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPIVCPVSRSSNEATSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLYTADSENEEDKRRTKKAKMKIEESSGVEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDISESEDSGPECTALKSIFTTEESESSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEIPIKRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVRQLYRYDKPVECGYHVKTEDPDLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRVQSRNYVDSSGSSLQNGKYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV
  
Inhibitor
Name:
BDBM50273477
Synonyms:
CHEMBL4129830
Type:
Small organic molecule
Emp. Form.:
C25H30F2INO3
Mol. Mass.:
557.4119
SMILES:
[I-].CCCCc1oc2ccccc2c1C(=O)c1cc(F)c(OCCC[N+](C)(C)C)c(F)c1
Structure:
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