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Target
Mu-type opioid receptor
Ligand
BDBM50013947
Substrate
n/a
Meas. Tech.
ChEBML_148837
Ki
2±n/a nM
Citation
 Lalinde, N; Moliterni, J; Wright, D; Spencer, HK; Ossipov, MH; Spaulding, TC; Rudo, FG Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics. J Med Chem 33:2876-82 (1990) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50013947
Synonyms:
CHEMBL95786 | Furan-2-carboxylic acid (2-methoxy-phenyl)-[3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-amide
Type:
Small organic molecule
Emp. Form.:
C24H28N2O3S
Mol. Mass.:
424.556
SMILES:
COc1ccccc1N(C1CCN(CCc2cccs2)CC1C)C(=O)c1ccco1
Structure:
Search PDB for entries with ligand similarity: