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Target
Proteasome subunit beta type-2
Ligand
BDBM50274034
Substrate
n/a
Meas. Tech.
ChEMBL_1713672 (CHEMBL4123721)
IC50
250±n/a nM
Citation
 Artschwager, R; Ward, DJ; Gannon, S; Brouwer, AJ; van de Langemheen, H; Kowalski, H; Liskamp, RMJ Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides. J Med Chem 61:5395-5411 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50274034
Synonyms:
CHEMBL4128074
Type:
Small organic molecule
Emp. Form.:
C27H46FN7O5S
Mol. Mass.:
599.761
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)CS(F)(=O)=O |r|
Structure:
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