Reaction Details Report a problem with these data
Target
Superoxide dismutase [Cu-Zn]
Ligand
BDBM50275725
Substrate
n/a
Meas. Tech.
ChEMBL_1715048 (CHEMBL4125097)
IC50
>100000±n/a nM
Citation
 Martín-Escolano, R; Moreno-Viguri, E; Santivañez-Veliz, M; Martin-Montes, A; Medina-Carmona, E; Paucar, R; Marín, C; Azqueta, A; Cirauqui, N; Pey, AL; Pérez-Silanes, S; Sánchez-Moreno, M Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi. J Med Chem 61:5643-5663 (2018) [PubMed]  Article 
Target
Name:
Superoxide dismutase [Cu-Zn]
Synonyms:
SOD1 | SODC_HUMAN | Superoxide dismutase
Type:
PROTEIN
Mol. Mass.:
15933.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1444880
Residue:
154
Sequence:
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
  
Inhibitor
Name:
BDBM50275725
Synonyms:
CHEMBL4128846
Type:
Small organic molecule
Emp. Form.:
C20H23N3O4
Mol. Mass.:
369.4143
SMILES:
COc1ccc(cc1)C(=O)CCN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Structure:
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