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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50276265
Substrate
n/a
Meas. Tech.
ChEMBL_1715485 (CHEMBL4125534)
IC50
12±n/a nM
Citation
 Atobe, M; Naganuma, K; Kawanishi, M; Hayashi, T; Suzuki, H; Nishida, M; Arai, H Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP Bioorg Med Chem Lett 28:2408-2412 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50276265
Synonyms:
CHEMBL4129545
Type:
Small organic molecule
Emp. Form.:
C19H12F3N3O2S
Mol. Mass.:
403.378
SMILES:
OC(=O)c1csc(Cn2nc(-c3ccccc3)c3ccc(cc23)C(F)(F)F)n1
Structure:
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