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Target
Delta(24)-sterol reductase
Ligand
BDBM50278872
Substrate
n/a
Meas. Tech.
ChEMBL_1719393 (CHEMBL4134393)
IC50
2.9±n/a nM
Citation
 Müller, C; Hemmers, S; Bartl, N; Plodek, A; Körner, A; Mirakaj, V; Giera, M; Bracher, F New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem 140:305-320 (2017) [PubMed]  Article 
Target
Name:
Delta(24)-sterol reductase
Synonyms:
1.3.1.72 | 24-dehydrocholesterol reductase | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase | 3-beta-hydroxysterol Delta-24-reductase | DHC24_HUMAN | DHCR24 | Delta(24)-sterol reductase | Diminuto/dwarf1 homolog | KIAA0018 | Seladin-1
Type:
PROTEIN
Mol. Mass.:
60115.66
Organism:
Homo sapiens
Description:
ChEMBL_117046
Residue:
516
Sequence:
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
  
Inhibitor
Name:
BDBM50278872
Synonyms:
CHEMBL4170755
Type:
Small organic molecule
Emp. Form.:
C29H42INO
Mol. Mass.:
547.5544
SMILES:
[I-].[H][C@@]1(CC[C@@]2([H])C3=CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)\C=C\c1cc[n+](C)cc1 |r,t:6|
Structure:
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