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TargetCysteinyl leukotriene receptor
LigandBDBM50227641
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52226
Ki 71±n/a nM
Citation Matassa, VGMaduskuie, TPShapiro, HSHesp, BSnyder, DWAharony, DKrell, RDKeith, RA Evolution of a series of peptidoleukotriene antagonists: synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles. J Med Chem33:1781-90 (1990) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cysteinyl leukotriene receptor
Name:Cysteinyl leukotriene receptor
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 98640
Components:This complex has 2 components.
Component 1
Name:Cysteinyl leukotriene receptor
Synonyms:CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:Enzyme Catalytic Domain
Mol. Mass.:38565.16
Organism:Homo sapiens (Human)
Description:Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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Component 2
Name:Cysteinyl leukotriene receptor
Synonyms:Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2
Type:Enzyme Catalytic Domain
Mol. Mass.:39657.52
Organism:Homo sapiens (Human)
Description:Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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BDBM50227641
NameBDBM50227641
Synonyms:CHEMBL297014
TypeSmall organic molecule
Emp. Form.C26H30N2O4
Mol. Mass.434.5274
SMILESCCn1cc(Cc2ccc(cc2OC)C(O)=O)c2cc(NC(=O)CC3CCCC3)ccc12
Structure
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n/a