Reaction Details
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5-hydroxytryptamine receptor 1D
Ligand
BDBM50015710
Substrate
n/a
Meas. Tech.
ChEBML_1633
IC50
190±n/a nM
Citation
Macor, JE; Burkhart, CA; Heym, JH; Ives, JL; Lebel, LA; Newman, ME; Nielsen, JA; Ryan, K; Schulz, DW; Torgersen, LK 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. J Med Chem 33:2087-93 (1990) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
Inhibitor
Name:
BDBM50015710
Synonyms:
4-Piperazin-1-yl-7-trifluoromethyl-pyrrolo[1,2-a]quinoxaline | 4-Piperazin-1-yl-7-trifluoromethyl-pyrrolo[1,2-a]quinoxaline(desmethyl-CGS-12066B) | CHEMBL28178
Type:
Small organic molecule
Emp. Form.:
C16H15F3N4
Mol. Mass.:
320.3123
SMILES:
FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Structure:
