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Target
Carboxypeptidase A1
Ligand
BDBM50283541
Substrate
n/a
Meas. Tech.
ChEMBL_1725649 (CHEMBL4140927)
IC50
470±n/a nM
Citation
 Testero, SA; Granados, C; Fernández, D; Gallego, P; Covaleda, G; Reverter, D; Vendrell, J; Avilés, FX; Pallarčs, I; Mobashery, S Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. ACS Med Chem Lett 8:1122-1127 (2017) [PubMed]  Article 
Target
Name:
Carboxypeptidase A1
Synonyms:
CBPA1_BOVIN | CPA | CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor
Type:
Enzyme
Mol. Mass.:
47073.90
Organism:
Bos taurus (bovine)
Description:
From Sigma-Aldrich Co.
Residue:
419
Sequence:
MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPGSPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTRSVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFKAFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQASGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
  
Inhibitor
Name:
BDBM50283541
Synonyms:
CHEMBL4176703
Type:
Small organic molecule
Emp. Form.:
C11H11FO2S
Mol. Mass.:
226.267
SMILES:
[H][C@@]1(CS1)[C@H](Cc1ccc(F)cc1)C(O)=O |r|
Structure:
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