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Target
Egl nine homolog 1
Ligand
BDBM50286250
Substrate
n/a
Meas. Tech.
ChEMBL_1728900 (CHEMBL4144178)
EC50
5800±n/a nM
Citation
 Ogoshi, Y; Matsui, T; Mitani, I; Yokota, M; Terashita, M; Motoda, D; Ueyama, K; Hotta, T; Ito, T; Hase, Y; Fukui, K; Deai, K; Yoshiuchi, H; Ito, S; Abe, H Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett 8:1320-1325 (2017) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50286250
Synonyms:
CHEMBL4159751
Type:
Small organic molecule
Emp. Form.:
C15H11ClN4O4
Mol. Mass.:
346.725
SMILES:
OC(=O)CNC(=O)c1c(O)cc(-c2cccc(Cl)c2)c2ncnn12
Structure:
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