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Target
Neuromedin-U receptor 1
Ligand
BDBM50291718
Substrate
n/a
Meas. Tech.
ChEMBL_1731393 (CHEMBL4146929)
EC50
5.1±n/a nM
Citation
 De Prins, A; Martin, C; Van Wanseele, Y; Skov, LJ; Tömböly, C; Tourwé, D; Caveliers, V; Van Eeckhaut, A; Holst, B; Rosenkilde, MM; Smolders, I; Ballet, S Development of potent and proteolytically stable human neuromedin U receptor agonists. Eur J Med Chem 144:887-897 (2018) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 1
Synonyms:
G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | GPR66 | NMU-R1 | NMUR1 | NMUR1_HUMAN | Neuromedin-U receptor 1
Type:
PROTEIN
Mol. Mass.:
47370.42
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103121
Residue:
426
Sequence:
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
  
Inhibitor
Name:
BDBM50291718
Synonyms:
CHEMBL4174679
Type:
Small organic molecule
Emp. Form.:
C57H80N16O11
Mol. Mass.:
1165.3457
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccc(O)cc2CN1C(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r|
Structure:
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