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Target
Histamine H1 receptor
Ligand
BDBM50017374
Substrate
n/a
Meas. Tech.
ChEBML_83773
IC50
42±n/a nM
Citation
 Walsh, DA; Franzyshen, SK; Yanni, JM Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds. J Med Chem 32:105-18 (1989) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50017374
Synonyms:
1-(4-{3-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone | CHEMBL17390
Type:
Small organic molecule
Emp. Form.:
C30H35NO4
Mol. Mass.:
473.6032
SMILES:
COc1cc(ccc1OCCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1)C(C)=O
Structure:
Search PDB for entries with ligand similarity: