Target
Mu-type opioid receptor
Ligand
BDBM50017407
Substrate
n/a
Meas. Tech.
ChEMBL_149148 (CHEMBL759239)
Ki
>100±n/a nM
Citation
 Bagley, JRWynn, RLRudo, FGDoorley, BMSpencer, HKSpaulding, T New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties. J Med Chem 32:663-71 (1989) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50017407
Synonyms:
CHEMBL161057 | Furan-3-carboxylic acid (6-chloro-pyrimidin-4-yl)-(1-phenethyl-piperidin-4-yl)-amide
Type:
Small organic molecule
Emp. Form.:
C22H23ClN4O2
Mol. Mass.:
410.897
SMILES:
Clc1cc(ncn1)N(C1CCN(CCc2ccccc2)CC1)C(=O)c1ccoc1
Structure:
Search PDB for entries with ligand similarity: