Reaction Details Report a problem with these data
Target
Heme oxygenase 1
Ligand
BDBM50315695
Substrate
n/a
Meas. Tech.
ChEMBL_1733252 (CHEMBL4148788)
IC50
900±n/a nM
Citation
 Salerno, L; Amata, E; Romeo, G; Marrazzo, A; Prezzavento, O; Floresta, G; Sorrenti, V; Barbagallo, I; Rescifina, A; Pittalą, V Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors. Eur J Med Chem 148:54-62 (2018) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50315695
Synonyms:
CHEMBL1192872
Type:
Small organic molecule
Emp. Form.:
C17H16N2O2
Mol. Mass.:
280.3211
SMILES:
OC(Cn1ccnc1)c1ccc(Oc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: